To prepare a GI cocktail with viscous lidocaine, mix 10-15 mL of viscous lidocaine 2%, 10-15 mL of liquid antacid, and 10-15 mL of diphenhydramine liquid (12.5 mg/5 mL) in a medication cup, creating a 30-45 mL mixture for temporary relief of gastrointestinal discomfort. The standard GI cocktail consists of liquid antacid alone, as research shows that adding other components provides no additional benefit for symptom relief. The GI cocktail does not refer to a specific product. Rather, it refers to a mixture of viscous lidocaine, an antacid, and an anticholinergic. [1][2] Viscous lidocaine works as an anesthetic to numb pain in the throat, esophagus, and stomach. “A GI cocktail is a mixture of medications used to relieve symptoms that cause gastrointestinal discomfort, such as heartburn, indigestion, or nausea,” says Matthew Hoscheit, M.D., a. A GI cocktail is a mix of meds used to relieve indigestion, chest pain, and GI discomfort. Learn how it works, its ingredients, uses, and possible side effects. A gastrointestinal (GI) cocktail is a mixture of medications that you can drink to help ease the symptoms of indigestion. A GI cocktail is a fast, short-term emergency-department mixture — antacid, viscous lidocaine, and often an anticholinergic — used to settle upper-gut pain while doctors work out its cause. The gastrointestinal cocktail, commonly referred to as the GI cocktail, is a liquid medication mixture administered primarily in acute care settings, such as emergency departments. It is designed to provide rapid, symptomatic relief from severe discomfort originating in the upper digestive tract. A GI cocktail is a combination of an antacid, viscous lidocaine, and an anticholinergic (Donnatal) used in hospital and emergency settings to treat indigestion and related symptoms. A GI cocktail is a facility-specific mixture used for dyspepsia, reflux-like pain, gastritis symptoms, or suspected esophageal irritation. It traditionally includes an antacid, sometimes viscous lidocaine, and sometimes an antispasmodic or anticholinergic medication.