What is a GI cocktail and how does it help with Acid Reflux? A GI cocktail is a mixture of 3 different types of medications that help with pain related to GERD and gastritis. A GI cocktail is a mixture of liquid medications given in the emergency department to quickly relieve upper digestive pain, particularly the burning, gnawing discomfort of dyspepsia (indigestion) or acid reflux flare-ups. The GI cocktail does not refer to a specific product. Rather, it refers to a mixture of viscous lidocaine, an antacid, and an anticholinergic. [1][2] Viscous lidocaine works as an anesthetic to numb pain in the throat, esophagus, and stomach. A GI cocktail is a liquid medication mixture for indigestion, combining antacids, viscous lidocaine, and anticholinergics. Discover what exactly is a GI cocktail and its use in emergency settings. “A GI cocktail is a mixture of medications used to relieve symptoms that cause gastrointestinal discomfort, such as heartburn, indigestion, or nausea,” says Matthew Hoscheit, M.D., a. The core idea behind a GI cocktail is to combine ingredients that address multiple facets of digestive distress. Typically, it aims to neutralize stomach acid, reduce spasms, and provide a soothing, coating effect on the stomach lining. The standard GI cocktail consists of liquid antacid alone, as research shows that adding other components provides no additional benefit for symptom relief. A GI cocktail consists of 3 different ingredients — an antacid, viscous lidocaine, and an anticholinergic called Donnatal. It’s used to treat indigestion and associated symptoms in hospital. A GI cocktail is a mix of meds used to relieve indigestion, chest pain, and GI discomfort. Learn how it works, its ingredients, uses, and possible side effects. A GI cocktail is a combination of an antacid, viscous lidocaine, and an anticholinergic (Donnatal) used in hospital and emergency settings to treat indigestion and related symptoms.